A week ago I gave him Trifexis because he had been on it a few years ago.the next night he had a seizure. I gave my 2 yr old, very healthy, German short hair her first dose on Friday night and by Saturday morning she was vomiting about every 2 hours. Its now about May 16th 2021. He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. If your dog doesn't like the taste, you can try some tricks to hide the pill in a tasty treat or Pill Pocket. The Vet's are so busy that even if you can get in you don't get anywhere. The door is open , its where he prefers to sleep on a doggie bed . Gave Simparica to my dog yesterday. The representative for the company says the half life is 16 days. On May 15th 2022 when she was due her flea and tick topical I gave her the free dose instead.Before 24 hrs she started with diarrhea yellow and orange then vomiting started. She also started with ear infections. He did blood work and found that the phosphorus levels in her blood were way to low and that was causing the neurogical problems and it was most likely from Simparica Trio. I dont like that my dog looks at me like he doesnt know who I am. Were there any other conditions? This is so scary. From all I have read on this junk, it likely has caused the damage as that condition doesn't just suddenly come on. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . I want to thank everyone who posted I could not find enough information on other sites. my vet recommended this for both my yorkies. I want to cry I wish I could get it out of her system after reading these comments. Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. He had an MRI and it came out good. Then she lost control of her legs and couldn't walk or stand. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. thank you. If she comes out of this I will return to heartworm pills and topical flea and tick meds. My one year old has severe diarrhea and is very agitated and anxious. not eating alor and wants me to rub her tummy constantly . Furious that this out there for pets. My 2 year old Shepherd was perfectly healthy in Feb. and by April of this year he quit eating, excessive thirst, excessive urination, low platelet count, low red blood cell count is unsteady and now is at a vet hospital and so far we have spent 2000 and they do not know what is wrong with him. We nurses him back into a happy healthy puppy and now this. Never had them ever and she's only 3 1/2 yrs old. He has become more aggressive and has been growling at me sometimes when I try to move him. Some adverse reactions to Simparica include tremors, decreased awareness of body movement, loss of control over bodily movements, problems blinking, and/or seizures. He had his second dose on 3rd July. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). That is the only thing that has changed in her routine. I just gave him heartgard and nexgard about 2 weeks with no issues. Now, here we are one month later and I just gave him the second dose about two hours ago. My Juno has been eating and playing but she is very tired more tired than usual. Not wanting to play, shivering, and drinking excessively. And he was on Comfortis before and did fine. My dog is 9 yrs old . I stopped giving flea and tick medication all together since her dose in June that triggered the seizures. I just want to cry! I take her everywhere as I'm terrified of it happening and her dying, we were convinced she was dying. She is absolutely miserable and we're hoping she makes it. They have increased and worsened over the last 3 months. All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. I am very worried I called the vet they said oops sorry they made a mistake. First month, the one threw up, same thing second month. Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. Do you have contact details that you can share with me. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . The neurologist I went to would not give him steroids until I did the spinal tap and MRI. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. My 5 year old Bichon Frises, Ivy, was on NextGard for years. 13 March he is also very lethargic and sitll not eating (even his favorite treats). She keeps running through the house as though looking for something. He looked like he was having spasms. We tried stopping the simparica. I have always used topical tx. I took him to the ER they checked his vitals and sent me home. HELP!! Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. Before sharing sensitive information, make sure you're on a federal government site. I'm so upset. Even when asked to go for a car ride he didn't respond. It's unique because it kills more types of parasites than any other combination product available to date. We are experiencing the same thing. How long did the itchiness last for your schnauzer? This all-in-one tablet can help make it easier to keep pesky parasites away this spring (and all year long). Simparica may show slide side effects in a few dogs like tremors, unsteadiness, and/or seizures but else it is Tested and FDA approved suits to 90% of dogs. Simparica is pretty new in England and it seems they are trialling it. She spent 4 nights at the University of Auburn emergency room and vet clinic. Maybe? This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. I hope and pray for no long term affects. I feel like the simperica trio has somehow affected his Pituitary/Andrenal glands are maybe even acting as blockers to them. Now do you get the connection? ALL oral tick meds are in the same class of drugs, so cannot give anything with that in it. He was diagnosed with "Sundowners" . I hate giving her these drugs in the first place but am always convinced it is the right thing to do. If anyone has suggestions or knows how else I can help my little guy please let me know. Can you tell me if your dog is back to normal now?!?! Let us now look at possible side effects when administering Simparica. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. It is like night and day compared to her regular personality or demeanor. Today started diarrhea & he has gone 5 times so far while not eating much. He had full wellness exam three ago and was in perfect shape. I will never use this product again!!!!! I just gave Bentlee my Akita Simparica Trio on the 9th. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. He is very friendly with other people and pets and never had an issue in that regard. Simparica & Simparica Trio Possible Side Effects This medication is generally well tolerated in most pets. so what about her puppies I am so worried. I even told them about the Simparica which they dont respond to. I can tell something is off with her I just couldnt figure it out. I won't sleep until we all get the justice for our babies that don't have voices of their own. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. What Are Potential Simparica Trio Side Effects in Dogs? Zoetis.com.au; Privacy Policy This links to a pdf file; Terms of Use This links to a pdf file Those with Diarrhea symptom, did it look like mucus in their pets stool? He had never pooped in the house and now he does every time he has to be put in his indoor pen for us to leave or sleep. Its crazy to think they dont recover and can die in a few months. Now Im scared ive been giving him Simparica Trio and it could be the cause of his progressively worsening sickness. We contacted the company using the phone number supplied in the under in the box and shared our experience with the new drug. I just gave my Matty her first dose. You don't think I'm going to continue with this poison. I sure hope we don't have ongoing problems. I gave my sweet little toy poodle Simpaica today, and one hour later this poor dog went from happy and healthy to having a terrible seizure. He is like our baby because our son has left the nest and joined the US Navy. We immediately gathered her up and took her to the vet. So we went home with her on steroids and more antibiotics and denamrin for liver. I couldnt figure it out until I googled all the medications the vet has prescribed for her then I came across this forum and I am pissed!! she has shaking off and on . Took him to the vet Potassium level was so high they did an ekg and his heart was not beating regular. I called my Vet and waited all day for them to call back, useless. He is still not himself, walks very slowly and is definitely not feeling his best. The only thing the vet told me was that his ATL liver enzyme levels were just slightly high (170) and it wasn't a concern and we could just do another blood test at his next check-up. He just isnt himself. I put water with electrolytes by his cage & food . The FDA considers this level to be "very rare". Thank all who have posted to bring this subject to light. I am also going to contact the vet who gave it to me and tell him all this stuff. I hope there will be a class action lawsuit but most importantly that the word get out to stop this medication from harming another life. She hasnt eaten in 3 days and is unable to go up 2 simple steps. Vet trip and meds $400! Please anyone let me know if there is a class action law suit or where we can start one? I'm so angry this medication is on the market. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. So, I gave it to him. Eight hours later and she has terrible diarrhea and vomiting, now she is not eating. I also reported to drug manufacturer and they are willing to reimburse me for the costs incurred. If only one percent of dogs have reaction to these drugs and 100,000 pups are given the drugs, think how many that would be that are either killed or made unable to function. Youre an idiot then! but wasnt allowed in with him. They did an ultrasound (2 of them), X-rays, blood test, gave fluids, did another ultrasound (looking for a master fluid that keeps popping up and going away between her stomach cavity & spinal cord. I'll be spreading the word. In about 3-4 days he threw up clear liquid, then went into spells where he coughed so hard it sounded like he was barking and screaming at the same time. Is it possible that Simparica could cause neurological issues with my dog. They immediately denied they were in the wrong for prescribing because any meds can have side effects but Im convinced this medication is poison. . This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. My dog weighs 60 pounds and was given a dose for dogs up to 88 pounds. Ive read these stories and am also disgusted. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. MONEY!!. I will not be continuing with this treatment. It comes as the first choice when prescribing a treatment due to its liver flavor. I sadly started my beautiful dog on Simparica Trio on May 1, 2021. Thanks! he didn't throw up but he doesn't want to go to bed at night and he just paces around the bedroom and sometimes goes under the bed. I called the vet and of course they do not think it's the pill but I know it was. I gave my dog his first dose the first week of April. When did you stop giving the Simparico Trio? This behavior is so inconsistent and confusing. This has gone on for about half of the day. We are now back to regular vet with bloodwork every two weeks and still on meds and diarrhea but not as bad. Simparica can cause ataxia, which is the official name for loss of body control. That night he seemed a little uncomfortable, unable to sleep, and I didnt think anything of it. They may not be ready to beat you in a game of chess, but these brainy dogs are easy to train and generally eager to please you. This morning was the first morning he left water in his bowl. He was in excellent health prior to this incident. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. The following list includes the known side effects of Simparica. Now I am terrified for his well being. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . I should have kept with my gut feeling about any of these oral meds. I would, still boil chicken, carrots, potatoes for his meals. Will be talking to the vet inregards to his side effects. We received the first dose of this medication from our Vet! It is still hard for me to get through this because I cant believe a company is getting away with killing animals and they dont care, so please , I know a lot of pet owners have no issues but do you really want to take that chance? Is there any good outcomes from this tablet? He had a serious skin issue a few months back and it was blamed on fleas. He is disoriented, his head just hangs and he is lifeless. RELATED: Signs Your Dog Might Be Having a Seizure. After spending the day at the ER Vet where they did bloodwork and several x-rays all coming back normal, they sent her home with Keppra. All we want to do is take the best care of our animals and trust the people (Vet's) who specialize in this to do what's right for them. We rushed him to the emergency vet and they put him on keppra to stop the seizures. Im not sure if the simperica is the cause. Vet put her on metronidazole which is working. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. She is healing and has no new rashes or sores. The more we complain the more chance we have of saving other dogs. Our golden retriever had his first seizure after taking Simparica Trio last October. Sorry but keeping it caged due to a suspected side effect is is uncalled for. I am up writing this 4 a.m. since our Lambchop is too restless to sleep! Work up from the neurologist shows all his tests came back negative. You seem like an idiot. Nothing they can do for her she said. I gave simparica trio to my 10-year-old Havanese. On August 17th, we had to rush him to the ER because he was not moving. She probabpy had some in her system (which is quite common, even for well-cated-for puppies), which would explain her diarrhea. This was the 2nd does I have him. In the meantime i keep trying to give him ice and i am very worried that i have permanently harmed him. And how do we get the word out to everyone? Our pup only made it 4 months after her first seizure, but this did seem to help her symptoms toward the end. These products are approved for the treatment and prevention of flea infestations, and the treatment and control of tick infestations. My dog (6 years old) has been using monthly Simparica since I got him. Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. I am so angry. I lost my girl 2 days after taking Simparica. While veterinarians often prescribe medications for off-label uses, your veterinarian will determine whether Simparica is right for your pet. Doesn't anyone here wonder why?, if this is sooo safe to use with mammals, isn't there a human version also available? Just hoping you can give me something good and tell me your dog recovered. Two months no flare up no more scabs and loosing hair. Meaning he is suppose to get it today. She was shaking like she was freezing. Our dog was killed by this poison within 15 hours after taking one dose. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. He said it would take care of ticks and Trifexis doesn't. There is also a chance that hell need a surgery. This is so awful. We did not make the connection until today. Zoetis claims it will be out of his system in two months and I should not see lasting effects, so I am hopeful but worried and telling everyone I know NOT to use this poison. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. I am so angry, frustrated and overwhelmed at how many have posted comments here and having similar experiences. Never again will I be giving my pets any pharma meds. Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. Please think these things through before subjecting your pet to internal insecticides. I should have know it was a sign when he spat it out. this link is to an external site that may or may not meet accessibility guidelines. I have been telling everyone not to give this to their furry ones!!!!!!!! I'll continue to watch her. I have always been apprehensive about putting my dog on Heartworm / Flea Tick medication because of horror stories, but I thought he's 5 and it will be from the vet and it seems like the responsible thing to do. A week after I lost her I got COVID and was in the hospital for 20 days. I just wanted to get another opinion before we move forward. Thursday morning was an awful beginning of the day for our boy. Eyes roll back. And both of my other labs, basically house dogs, ended up with a droopy left eye. I have been giving my lab puppy (6 months old now) Simparica Trio since October. Simparica Trio can be administered to your dog at any age, but it's best to start treating your dog one month before the fleas become active. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. Hearing 35-40 to leave systems. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. Vet thinks it may be Addision disease and wants to test for it. Hi how is your pup now? Poor dog prob thinks HE did something wrong. What Are The Side Effects Of Simparica Trio For Dogs? This happened to our 2yr old frenchie last Friday. Daily Paws is part of the Meredith National Digital Network. Will not be using this treatment again!!! Gave my 12 year old labradoodle simpatico just before going to my sons for T-Day dinner. I know Dukes problems were from this medicine, and it upsets me that my vet told me that this medicine was safe! My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. 300+ Cute Cat Names for Every Kind of Kitty. My pup is scheduled to see a neurologist Monday ( today's friday) to evaluate. Could this be caused by the med? Good appetite and no digestive issues (never had that symptom). I have to turn him around and lead him away. Everything else in his environment, world has remained the same. Zoetis (Simparica, Simparica Trio, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see How to Report Animal Drug and Device Side Effects and Product Problems. Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. She said to watch for drainage. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. Instead it has become a world of greed. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). The vet has reported it (at least she too thinks it came from the drug) and a chiropractor checked her for the possiblility of slipped disc etc and said it's not that. She has episodes where she seems very anxious and is hiding under car/tables/beds. My poor puppy has to go under anesthesia on top of. Will never use again. Although the mother that took the same had not shown any effects. Hard fast shaking and terrified eyes. Can blocking GABA receptors also cause inflammation of spine? I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. Saving money sounds great, right? Please do NOT try Simparica Trio, I went to the Vets office to pick up Dukes Revolution Heart Worm meds, and they talked me into switching to Simparica Trio, we gave Duke his first dosage on March 1st, March 2nd, he would fall down while walking, he would fall down trying to get up, he's NEVER done this before! I got my dog Josey up to let him out to pee. Well, let me tell you: THANK YOU ALL FROM THE BOTTOM OF MY HEART. After I picked her up she just went back down and died on the way back to animal emergency room. Took a dose of simparica trio.second rose in second month.dog is having tremors. Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. I'm more concerned about fleas and heartworms and Trifexis is just fine for that. Never saw tremors before. Im just hoping my sweet girl is going to be ok. My English Springer Spaniel(Sadie) received her first dose of Simparica Trio at 12 weeks old, with no noticeable side effects. This is an eye opener for me! Hes very lethargic and constant vomiting! He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. This time he is having seizures. The Trio product by Simparica is a three-in-one medication to control and prevent flea, tick, and heartworm. Not to worry you, and I hope yours is different outcome! This dog was my partner and friend. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. now almost exactly two months later, sick again with a fever and stops eating. And it looks like the liver and/or the kidney will not take it too. Now tremors started. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). He loves the taste of Simparica Trio and it's like a treat for him. Even when we specifically mentioned the new information he still had nothing but the original tests to go off of. Hi Charlene, can you elaborate on agitated swallowing? Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. Chicken, carrots, potatoes for his meals ultimately spend 5 days and is unable to sleep to continue this!, still boil chicken simparica trio for dogs side effects carrots, potatoes for his meals to me and him. No issues serious simparica trio for dogs side effects issue a few months back and it seems they are willing to reimburse me for costs! 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